PCoIP did not resolve the issue I guess I was trying to ask if they have included an option to connect to the client like the vmware Infrastructure client does which communicates to the virtual machine through the ESXi host instead of communicating to an agent that is running directly on the VM.
As far as it being a cisco question.....if the company providing the VPN profile chooses to allow local LAN access in the VPN profile it still works, but if they do not for security reasons then you cannot connect to an agent running on the virtual machine.